Home»Biochemistry» Evaluate the rationale use of nonsteroidal anti-inflammatory drugs (NSAIDs) in laborers/ heavy workers in Katsina central market

Evaluate the rationale use of nonsteroidal anti-inflammatory drugs (NSAIDs) in laborers/ heavy workers in Katsina central market

 Department: Biochemistry  
 By: usericon EmmyICT  

 Project ID: 7634
   Rating:  (5.0) votes: 1
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Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to relieve pain and inflammation. However, conventional NSAIDs (e.g., Diclofenac, Meloxicam, Ibuprofen) can induce gastrointestinal (GI) upset and adverse events, especially peptic ulceration. To reduce this risk, gastro-protective agents are commonly co-prescribed with NSAIDs alternatively, cyclooxygenase (COX)-2 inhibitors (e.g., Etoricoxib, Celecoxib) are used, a new generation of NSAIDs claimed to cause fewer gastrointestinal adverse events. Co-prescription of COX-2 inhibitors with gastro-protective agents are recommended only in patients at high risk of GI disease, such as elderly patients (aged= 60 years), those using antiplatelet agents (e.g., Aspirin), or patients with a history of GI events. Commonly used gastro-protective agents are histamine H2-receptor antagonists (H2RAs, e.g., Ranitidine) and proton pump inhibitors (PPIs, e.g., Omeprazole, Pantoprazole, Esomeprazole, Lansoprazole). The H2RAs competitively antagonize the histamine effects at H2-receptors in the stomach to reduce the amount and concentration of gastric acid. PPIs suppress stomach acid secretion by specific inhibition of the H+/K± ATPase system found at the secretory surface of gastric parietal cells. Concomitant use of H2RAs and PPIs are recommended only in the treatment of gastro-oesophageal reflux disease (GORD)....
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