Effect of garlic and ginger co-administration on serum glutathione levels of Wistar rat exposed to vanadium, lead and arsenic Department: Biochemistry By: ultimeight Project ID: 5692 Rating: (3.3) votes: 6Rate this project12345 Price:₦3000 Get the Complete MaterialAbstractOxidative stress in blood and other soft tissues has been postulated to be one of the possible mechanisms of heavy metal-induced toxic effects. Therefore, this present study aims at evaluating the abrogative effects of garlic and ginger co-administration on serum antioxidants in Wistar rats exposed to arsenic (As), vanadium (V) and lead (Pb) by assaying for the serum glutathione (GSH) level. Thirty-five wistar rats weighing 100-150g were randomly divided into seven (7) groups of five (5) animals each and were administered treatments as follows Group A (normal control) received distilled water only group B (HM only) received sodium arsenite (2.5 mg/kg b.wt), lead acetate (60 mg/kg b.wt) and vanadium pentaoxide (9.8 mg/kg b.wt) group C (HM + GI1 + GA1) received HM + ginger (100 mg/kg b.wt) + garlic (100 mg/kg b.wt) group D (HM + GI2 + GA2) recieved HM + ginger (200 mg/kg b.wt) + garlic (200 mg/kg b.wt) group E (HM + VITC) recieved HM + vitamin C (100 mg/kg b.wt) group F (GI1 + GA1) received ginger (100 mg/kg b.wt) + garlic (100 mg/kg b.wt) and group G (GI2 + GA2) recieved ginger (200 mg/kg b.wt) + garlic (200 mg/kg b.wt). All treatments were orally administered daily, for four weeks. From the results of this study, arsenic, lead and vanadium exposure provoked a 26.3% increase in the GSH level when compared to the normal control group. From the study ginger (Zingiber Officinale) and garlic (Allium sativum) were also shown to enhance the GSH levels of a normal rat and its efficiency almost on par with vitamin C, a well-known potent antioxidant....Preview Download Preview +Other Biochemistry project topics and materials you might be interested in»Phytochemical and nutritive composition of fluted pumpkin»Determination of ascorbic acid in selected fruits mango, orange and pineapple using spectro-photometric method»Comparative evaluation of heavy metal loads in some selected soft drinks in Owerri, Imo state»Antilipidemic effect of water (H2O) extract of desmodium velutinum leaves on albino Wistar rats»The effect of water extract of cola nitida pod on lipoprotein concentrations of albino Wistar rats»Preliminary investigation on effects of burantashi extract on lipoproteins of albino male and female whistar rats»The extraction of manganese (iv) ion from aqueous media using 1-phethyl-3-methyl pyrazolone-5»Nutritive value, anti-nutrient and mineral composition of cashew nut (Anacardium Occidentale)»Evaluation of the immunomodulatory effect of oral administration of the methanol extract of gongronema latifolium (utazi) in wistar albino rats»Comparative study on the free radical scavenging potential of turmeric and beetroot»Phytochemicals and minerals analysis of rosary pea (Abrus Precatorious leaves)»Determination of total petroleum hydrocarbons in Niger river»Qualitative phytochemical and gas chromatography mass spectrometry GCMS of Nhexane extracted leaves of sabicea calycina»Hydrogen peroxide scavenging activities and reducing power of various fruits juice in Yenagoa»Charges in the concentration of nitric oxide in the serum gills brain liver and kidney of clarias gariepinus exposed to glyphosatebased herbicide